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Niflumic acid : ウィキペディア英語版 | Niflumic acid
Niflumic acid is a drug used for joint and muscular pain. It is categorized as an inhibitor of cyclooxygenase-2. In experimental biology, it has been employed to inhibit chloride channels. It has also been reported to act on GABA-A〔Sinkkonen ST et al. (2003): ''Receptor subtype-dependent positive and negative modulation of GABA(A) receptor function by niflumic acid, a nonsteroidal anti-inflammatory drug'', ''Mol Pharmacol'', p. 753-63. PMID 12920213〕 and NMDA channels and to block T-type calcium channels.〔Balderas E et al. (2012): ''Niflumic acid blocks native and recombinant T-type channels'', ''J Cell Physiol'', p. 2542-55. PMID 21898399〕 ==References==
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